EstrAir Advancing precision localized estrogen therapy

Advancing Precision Localized
Estrogen Therapy

EstrAir is developing precision localized estrogen therapies designed to restore estrogen-responsive tissues through targeted delivery while minimizing systemic exposure.

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Why Localized?

Targeted Where It Matters Most

Instead of exposing the entire body to hormone therapy, EstrAir is developing technologies that precisely deliver micro-dose estrogen to estrogen-responsive tissues where restoration is needed.

This approach is designed to maximize local therapeutic effect while minimizing the systemic hormone burden — a fundamental shift in how estrogen therapy is conceived and delivered.

Precision Delivery

Targeted micro-dose administration to specific tissue sites

Localized Therapy

Estrogen delivered where restoration is needed, not systemically

Minimal Systemic Exposure

Designed to reduce whole-body hormone burden

Platform Expansion

Scalable technology across multiple estrogen-responsive tissues

Areas of Scientific Interest

Estrogen-Responsive Tissues

Our platform has potential applications in estrogen-responsive tissues including the following areas of active scientific interest.

Oral Health

Localized therapy for oral mucosal and salivary tissues. Estrogen plays a key role in maintaining mucosal integrity, salivary gland function, and tissue hydration throughout the oral cavity.

Upper Airway

Localized estrogen delivery to upper airway tissues. Estrogen receptors are present throughout the upper airway and may influence tissue tone, mucosal health, and airway patency.

Voice & Laryngeal Health

Supporting estrogen-responsive tissues involved in vocal function. The larynx contains estrogen receptors, and hormonal changes are known to affect vocal fold structure and voice quality.

Future Applications

Precision localized delivery across additional estrogen-responsive tissues. EstrAir's platform is designed for expansion as the science of localized hormone therapy continues to evolve.

Investigational only. EstrAir's technologies are in early-stage development. All potential applications are investigational and have not been evaluated or approved by the FDA or any regulatory authority.
Scientific Foundation

The Biology Behind the Platform

Estrogen receptors are present throughout numerous tissues that rely on estrogen for normal structure, hydration, and function. When estrogen declines — as it does during perimenopause and menopause — these tissues can undergo significant structural and functional changes.

EstrAir is developing localized delivery technologies designed to restore tissue health at the site of need while minimizing systemic exposure. Our approach is grounded in the established biology of estrogen receptor distribution and tissue-specific estrogen dependence.

ERα/β
Estrogen receptors found throughout oral, airway, and laryngeal tissues
1B+
Women globally affected by menopause-related tissue changes
Estrogen Receptor Presence by tissue type (illustrative) Oral Mucosa Salivary Glands Upper Airway Laryngeal Tissue Low Med High EstrAir target tissues Laryngeal focus
Our Vision

"Rather than treating the entire body, what if we could restore exactly the tissue that needs it?"

EstrAir is building a platform for
precision localized estrogen therapy.

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Leadership

Our Founder

Amy Urban, DMD — Founder & CEO of EstrAir
Amy Urban, DMD
Founder & Chief Executive Officer

Amy Urban, DMD is a dentist and entrepreneur with deep clinical expertise in oral medicine and a focused interest in the intersection of hormonal health and tissue biology. Her clinical observations of estrogen-related changes in oral and airway tissues led her to identify a significant unmet need: the absence of targeted, localized estrogen delivery for the tissues most affected by hormonal decline.

Dr. Urban founded EstrAir to address this gap — developing a platform designed to deliver precision localized estrogen therapy to estrogen-responsive tissues while minimizing systemic exposure. Her work bridges clinical dentistry, women's health, and precision medicine.

EstrAir is currently in early-stage development. Dr. Urban is actively building the scientific, clinical, and business foundation for the company.

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We'd love to hear from you.

Whether you're a potential investor, scientific collaborator, clinician, or simply curious about our work — we welcome the conversation.

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